Parkinson's disease (PD) is a neurodegenerative disease of the central nervous system. It is a chronic, long-standing, progressive course. No cause is unknown, but recently have discovered the existence of genetic abnormalities in families in which the majority of its members were affected and in familial cases of Parkinson's disease early presentation (age of onset below 40 years). However, most patients with sporadic Parkinson's have a presentation that is no clearly identified genetic factors.
Arguably, no single cause, and there are familial cases with known genetic abnormalities and other cases in which a combination of genetic and environmental factors would be responsible for neuronal death.
The most common symptoms are related to the movement: tremor, lack of automatic movements such as blinking or walking arm movement, the inclination of trunk forward during walking, and so on. With increasing disease duration, other symptoms appear, such as a deterioration in gait.
Incidence
The maximum age at presentation is 60 years from the gradually increasing to age 80. The incidence in this age is a 1-2/1.000 of the population. However, there are cases presenting at a younger age and can occur at any age from the second decade. It affects almost equally to both sexes.
The EP is a disease of clinical diagnosis. This means it is the neurologist who, with data provided by the patient and his family in the history and physical examination findings, diagnoses the presence of PE.
Because they think it is a major disease, it is strange that a young person to have. That's what happened to Jose Luis Molero, which at the first did not recognize the Parkinson symptoms. Of course, "affects 100% in your life: work, personal etc. It is a blow. "
Treatments
As for his treatment is based on the replacement of cerebral dopamine using pharmacological administration of levodopa. However, chronic administration of the drug several times a day is associated with motor complications in the medium to long term. In cases where pharmacological measures fail to control the patient's problems, surgical treatment or stimulation by causing malfunctioning of brain structures in PD, such as the subthalamic nucleus or globus pallidus interna, is another therapeutic option with good results in large series of patients with years of monitoring.
But they are also very important, says Molero, alternative therapies, physiotherapy, speech therapy, music therapy, etc..
Saturday, November 12, 2011
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